Today the elderly are more than the young but the funds for the health system are decreasing. The medicine paradigm must be rethought. E-Health can be the solution to support for the delocalization of some medical services, The ability to combine the power of AI algorithms and data from different sensors and databases can greatly increase the reliability of the final choice of the right therapy. This is the new Medicine 4.0. The digitalization of the processes and the improvement of technology allow interfacing the human body with computers and Artificial Intelligence allows you to work with a large amount of data (big data) and identify unknown correlations between the parameters to allow a new diagnosis. Several new perspectives will be discussed in this presentation. We will investigate both new technologies showing wearable devices that can be used both to monitor patients at home (this topic was very important with the Covid 19) and Artificial Intelligence applied to medical image processing to perform remote diagnoses (once again used to distinguish pneumonia from lung problems due to Covid 19).